Interpreting Metabolic Route Search

asked 2017-11-14 17:01:02 -0500

gpharhay gravatar image

I performed a metabolic route search and generated output that isn't easy to interpret.

Starting compound: fumarate Goal compound: 8-amino-7-oxononanoate

Generated a 2-step route involving 2 enzymes, fumarate oxidoreductase (deaminating) and a putative 8-amino-7-oxononanoate synthase . Problem is that it isn't clear to me how the products of the first reaction (2-iminosuccinate, succinate, H+) are reactants in the second (a pimeloyl-[acp], L-alanine, H+). The 2-iminosuccinate is supposedly a dead-end compound, so I'm guessing that succinate and H+ give rise to a pimeloyl-[acp]. Seems like a step or two is missing.

I'd like to attach a pdf that visually depicts the route BioCyc found, but I can't because I need 10 points to upload. Suggestions?

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