Can I improve pathway calculation by adding Tier3 relatives?
When I use Pathway Tools to make a new database for a new organism, does it make sense to load Tier3 databases of closely related organisms into Pathway Tools to get more pathways? I mean, the Tier3 databases are calculated from what is already in Pathway Tools so it might not make sense, but they provide combinations of enzymes as occurred in related species so does that help Pathway Tools calculate more pathways?